Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care. You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved. These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand.
You may want to review these resources with a medical professional. Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. National Institutes of Health. COVID is an emerging, rapidly evolving situation. Menu Search Home Diseases Chronic active Epstein-Barr virus infection. You can help advance rare disease research!
This site is in-development and may not reflect the final version. Preview the new GARD site. Other Names:. Viral infections. Summary Summary. Symptoms Symptoms. These features may be different from person to person.
Some people may have more symptoms than others and symptoms can range from mild to severe. This list does not include every symptom or feature that has been described in this condition. Over time, CAEBV can lead to failure of the immune system which, if not treated, can lead to potentially life-threatening complications. Showing of 8 View All. Permanent enlargement of the airways of the lungs.
Decreased immune function. Frequent respiratory infections. Multiple respiratory infections. Susceptibility to respiratory infections. J Med Virol —7. Acta Paediatr Jpn —9. J Infect Dis —8. J Med Virol —8. Med Microbiol Immunol —8. Clinical significance of variations in levels of Epstein-Barr virus EBV antigen and adaptive immune response during chronic active EBV infection in children. J Immunotoxicol — Ann Hematol — Kimura H. Pathogenesis of chronic active Epstein-Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency?
Rev Med Virol — Characterization and treatment of chronic active Epstein-Barr virus disease: a year experience in the United States. Blood — Google Scholar. Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. Am J Hematol —9.
Clinical features of adult-onset chronic active Epstein-Barr virus infection: a retrospective analysis. Int J Hematol —9. Prognostic factors for chronic active Epstein-Barr virus infection. Distribution and phenotype of Epstein-Barr virus-infected cells in human pharyngeal tonsils.
Mod Pathol — Adv Cancer Res — Epstein-Barr virus. Fields Virology. J Gen Virol — Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection. J Infect Dis —9. Leuk Lymphoma — J Infect Dis —7. Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection.
Can Med Assoc J — PubMed Abstract Google Scholar. A case of severe chronic active infection with Epstein-Barr virus: immunologic deficiencies associated with a lytic virus strain. Clin Infect Dis — Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis.
Clinical and serologic features and response to antiviral chemotherapy. Ann Intern Med — Alfieri C, Joncas JH. J Virol —9. A familial syndrome of susceptibility to chronic active Epstein-Barr virus infection. Can Med Assoc J —4. Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation. Haematologica —7. J Clin Immunol —8. Nat Immunol — Nature —6. Clin Infect Dis —7. CTP synthase 1 deficiency in successfully transplanted siblings with combined immune deficiency and chronic active EBV infection.
J Clin Immunol —3. Your doctor can find the virus by testing your blood for antibodies, but the virus usually remains dormant.
The virus may be more likely to reactivate and cause symptoms in people who have a weakened immune system. This includes people who:. If you have EBV, you can still develop mono caused by another virus. If you have a healthy immune system, immune cells called natural killer NK cells and T cells work to kill EBV-infected cells in the blood.
And in some cases, even a healthy immune system can be overwhelmed by the virus. When this happens, high levels of EBV remain in the blood. Chronic active EBV infection is more common in people from:.
Genes may also play a role in the disease. Symptoms like fever and sore throat should go away within a couple of weeks. You may experience fatigue and swollen lymph nodes for a few more weeks. Persistent fatigue may be a sign of chronic EBV infection.
See your doctor if your fatigue lasts for more than a month after mono has been diagnosed. Myalgic encephalomyelitis ME , formerly known as chronic fatigue syndrome , is often mistaken for mono. Fatigue is one of the hallmark symptoms of both illnesses. And like mono, ME can cause a sore throat and swollen lymph nodes. Tiredness can last for many months after a mono infection, which has led some experts to believe that EBV causes ME. However, no link between the two conditions has been proven.
Strep throat is a bacterial infection of the throat. In addition to the symptoms of mono, strep throat can cause:. Influenza flu is a viral infection of the respiratory tract. In addition to the symptoms of mono, the flu can cause:. Cytomegalovirus CMV is another common virus.
It affects people of all ages. Hepatitis A is a viral infection of the liver.
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